Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells
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چکیده
منابع مشابه
ZGDHu-1 and fludarabine have a synergistic effect on apoptosis of chronic lymphocytic leukemia cells.
Previously, it was demonstrated that the novel proteasome inhibitor N,N'-di-(m-methylphenyi)-3,6-dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide (ZGDHu‑1) possesses activity against chronic lymphocytic leukemia (CLL). In the present study, we attempted to assess whether this drug has a synergistic effect with fludarabine on the apoptosis of CLL cells. Annexin V/PI staining, mitochondria...
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chronic myeloid leukemia (CML) is a myeloproliferative disorder with an average duration of 3 years. The fatal course CML patients on conventional therapy (including radiation, splenectomy and chemotherapy) has prompted an investigation of new treatments for the chronic phase of the disease because allogeneic bone marrow transplantation, the only potentially curative treatment modality known, i...
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Purine analogs are among the most effective chemotherapeutic drugs for the treatment of chronic lymphocytic leukemia (CLL). However, chemoresistance and toxicity limit their clinical use. Here, we report that the DNA polymerase inhibitor aphidicolin, which displayed negligible cytotoxicity as a single agent in primary CLL cells, markedly synergizes with fludarabine and cladribine via enhanced a...
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ژورنال
عنوان ژورنال: Annals of Hematology
سال: 2010
ISSN: 0939-5555,1432-0584
DOI: 10.1007/s00277-010-0988-z